Yep. Just like you would a plain ol' central line. Think about where the PICC line comes to rest: same place as a central line. The same hazard exists with a PICC, that is, air embolism. So we d/c them in the same manner as other central lines. The only difference between a central line and a PICC is that the PICC is peripherally inserted (the name almost gives it away...

).