To question 2)
Propofol is used on my ICU to some patients for a really lomg time, without any problems.
But there are reports about people, have experienced severe problems because of propofol. One very critical thing, you have to look at is rhabdomyolysis, which can occur, because of a reduced energy production while there is a increased energy need in the heart- and skeleton muscles.
The pharmacological commision of the german physicians provides the use of Propofol for not longer than 7 days.
Greetings
Dirk
(
http://www.akdae.de/20/20/Archiv/2004/200412101.pdf)