[Emmanuel Goldstein]

Originally Posted by GrumpyRN63

I've worked onc forever,I've never seen it as a gtt

This was back when it first came out. Premed, then a continuous infusion after the chemo. Our docs played with this for a while, but it didn't seem to be any more effective.

Pharmacokinetics: Pharmacokinetic studies in human volunteers showed peak plasma levels of 20 to 30 ng/mL at around 1 1/2 hours after an 8 mg oral dose of ondansetron. An 8 mg infusion of ondansetron reached peak plasma levels of 80 to 100 ng/mL. Repeat dosing of an 8 mg tablet every 8 hours for 6 days increased the peak plasma value to 40 ng/mL. A continuous i.v. infusion of 1 mg/hour after the initial 8 mg loading dose of ondansetron maintained plasma levels over 30 ng/mL during the following 24 hour period.
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Initial Dose: 8 mg infused i.v. over 15 minutes given 30 minutes prior to chemotherapy; or 8 mg infused i.v. over 15 minutes, given 30 minutes prior to chemotherapy, followed by 1 mg/h by continuous infusion for up to 24 hours; or 32 mg diluted in 50 to 100 mL of saline or other compatible infusion fluid and infused over not less than 15 minutes**, given 30 minutes prior to chemotherapy.


**No significant differences in terms of emesis control or grade of nausea have been demonstrated between the 32 mg single dose, the 8 mg single dose, or the 8 mg dose followed by the 24 hour 1 mg/hour continuous infusion.**

http://www.rxmed.com/b.main/b2.pharm...Z)/ZOFRAN.html

[marikat534]

I have given Zofran PO and Zofran IVP, but never IM. I have never heard of a drip, but guess it isn't impossible.

[kmoonshine]

I don't know about zofran drips, but they also have zofran pumps -mainly used in patients with severe hyperemesis gravidarum that does not respond to traditional treatment. I believe it is similar to how an insulin pump works.

[sharann]

When my dad had chemo they gave IVPB Zofran 32mg, over 15-30 minutes

[concededrn]

Originally Posted by sharann

When my dad had chemo they gave IVPB Zofran 32mg, over 15-30 minutes

that's exactly what I was going to say. I did chemo for 6 months when I first graduated.

[?burntout]

Originally Posted by kmoonshine

I don't know about zofran drips, but they also have zofran pumps -mainly used in patients with severe hyperemesis gravidarum that does not respond to traditional treatment. I believe it is similar to how an insulin pump works.

I have seen a Zofran drip a couple of times on the floors but I had a continuous Zofran pump with my last pregnancy (I had severe hyperemesis).

[Babs0512]

We give Zofran all the time in PACU with LR and we've never had a problems, but you better believe I'm going to check out that compatibility now!

[owensmommy]

Originally Posted by Babs0512

We give Zofran all the time in PACU with LR and we've never had a problems, but you better believe I'm going to check out that compatibility now!

Jeez, let me know what you find out...I also have given Zofran MANY times through an LR line!!

[Fiona59]

Up here IV Zofran is a pretty routine order post-op. Usually q6h. Just give it over 15 to 30 minutes. I've only ever heard of one patient having an allergic reaction to it. We usually have the choice of Zofran or Maxeran for post-op nausea.

[Babs0512]

I've only given Zofran IV but it can be given IM or PO (the tablets). I've never seen a Zofran gtt, however, if I ever need a PCA, I will request one!! Narcotics make me sooooo very ill, I vomit if I even think of a narcotic