I had a co-worker that used PEPID. He didn't have a Treo, he had a DELL Axim but he loved the program. I took a look at it and it seemed like a great program. I used Epocrates but that was on recommendation from one of our ER docs(I was playing in the ED at the time). So, have her try the free trial and see what she thinks. If she doesn't like it, you haven't lost any money! I wish your wife the best.
Christie