Originally Posted by sc1973
I am having a hard time getting started with dimensional analysis on certain problems. I hope someone can please help. Here's the problem. I know its simple to calculate, which I have done and gotten an answer, but I'm unsure of how to set it up with DA. Help please. The problem:
Dosage ordered: 10mcg/kg/day. Client weight: 68kg. Dosage available: 5mg/ml. What is the daily dosage?
When you are setting up problems using dimensional analysis, one of your goals is to set up the equation so that the labels that will be left and remaining with the number in the numerator and the number in the denominator of your final answer
are the labels you want and are in their correct position of the final fraction. All the other labels will have cancelled out because a label in the numerator of one of the terms in the equation matches with and cancels out the same label in the denominator of one of the other terms in the equation.
The equation still includes the dose you desire divided by the dose on hand. When you start by using that formula you end up with a very complex fraction which has to be broken down into simple terms by sequentially simplifying the denominator until you reach a series of fractions that contain only one term in the numerator and one term in the denominator. That is done, if you will recall from math, by multiplying the numerator and the denominator of this monster fraction that you are going get when you divide the dose desired by the dose on hand by the reciprocal of what forms the fraction at the bottom of this monster in order to end up with a denominator of "1". Remember from math that whatever you multiply the denominator by you must also multiply the numerator by as well--in effect you are multiplying by a complex fraction that itself actually reduces to the number 1. You retain the numerator of the reciprocal, which is itself a fraction with a denominator of "1", after it is mutiplied with the denominator of the monster complex fraction you are reducing. You can now just eliminate the "1"
on the reciprocal that is left because it is not needed and because any numerator over a denominator of 1 is equivalent to what is in the numerator (by identity). What's left of the reciprocal now becomes a term that becomes part of an equation you are starting to build.
Do not do anything with the "1" that remains in the denominator of the complex fraction you are simplifying, however, or your problem is not going to come out correct. Keep repeating this simplification process
with the complex fraction only until you are left with simple fractions (one term in each numerator and one term in each denominator). Starting with
dose desired divided by dose on hand results in this complex fraction (what a monster!):
10 mcg/1 kg/1 day (dose desired) / 5 mg/1 mL (dose on hand)
Begin simplifying:
10 mcg/1 kg/1 day / 5 mg/1 mL X 1 mL/5 mg/1 mL/5 mg (the reciprocal)
results in: 10 mcg/1 kg/1 day/1 x 1 mL/5 mg
Simplify again:
10 mcg/1 kg/1 day/1 x 1/1 day/1/1 day (the reciprocal)
results in: 10 mcg/1 kg x 1/1 day
Simplified, that complex monster becomes an equation of 3 simple fractions (I highlighted them in blue). If you study the resulting equation closely you will see how the mathematical manipulation of multiplying with reciprocals has resulted in a flipping around of what is in the numerators and denominators of the various fractions. Work this out on paper if you have to in order to see how the magic happens. Now you have this resulting equation:
10 mcg/1 kg x 1/1 day x 1 mL/5 mg (I've highlighted the terms you want in the final answer in red. You want mL in the numerator and day in the denominator of your answer)
To complete the calculation of the problem, you need to include the patient's weight and a conversion factor that changes the
mcg to
mg in order to clear those labels from the equation. Keep in mind that conversion factors are actually a manipulation of the use of the number 1 (if the numbers in the numerator are equal to the numbers in the denominator the fraction reduces to the number 1 AND any number multiplied by 1 is equal to itself). You perform the math with the numbers that are remaining:
10 mcg/1 kg x 1/1 day (these two fractions are the dose desired) x 1 mL/5 mg (dose on hand) x 68 kg/1 (patient's weight) x 1 mg/1000 mcg (conversion factor) = 680 mL/5000 day (notice that the labels mcg, kg and mg have all cancelled each other out which is what you wanted) = 0.136 mL/1 day (simplified)
It is generally best to work out DA in a step-by-step way on a piece of paper so nothing gets left out or forgotten. Some of these DA equations can get long depending on how many conversion factors you have to use. If the patient's weight had been given to you in pounds instead of kg, you would have had to apply another conversion factor to the DA equation and sequence the terms in the numerator and denominator positions so that other labels in the DA equation would cancel out.