There is primary (acute phase), secondary, latent and late (tertiary) syphilis.
Primary syphilis - most infectious stage, Incubation period ranges from 2 days to 12 weeks after exposure and averages 3 weeks.
- ulcerative, painless lesions (chancre) produced by spirochetes appears at the point of entry into the body
- small fluid filled lesion (chancres) on the genitalia, anus, finger, lips and or tongue
- female patients may have chancres on the cervix or vaginal wall
- unilateral or bilateral adenopathy in these same areas
- untreated, the chancres of primary syphilis heal in 2 to 8 weeks and disappear without leaving any scar
Secondary syphilis - highly infective stage occurs about 3 to 6 weeks after the primary stage - this stage may overlap with the primary stage - new lesions appear on the skin and mucous membranes along with systemic symptoms and generalized lymphadenopathy
- headache
- malaise
- nausea and vomiting
- weight loss and anorexia
- sore throat
- fever
- mucocutaneous lesions
- a macular, papular, pustular or nodular rash
- uniform, well defined, generalized lesions that are widespead and bilateral
- macules that erupt between rolls of fat on the trunk and the proximal arms, palms, soles, of the feet, face and scalp
- enlarged, erosive pink or grayish white lesions (condylomata lata) in the moist body areas, particularly the perineum, vulva and groin - they are highly contagious
- chancres appearing in this stage may become necrotic
- alopecia
- brittle, pitted nails
- generalized lymphadenopathy
Latent syphilis- usually no physical signs as the infection lie dormant
- possible recurrence of the mucocutaneous lesions seen in secondary syphilis
Late or tertiary syphilis - the spirochetes have entered into the internal organs, causing permanent damage with symptoms occurring 10 to 30 years after the untreated primary lesions
- Depends on the organs involved. There are 3 subtypes
- Neurosyphilis
- when meningovascular tissue is affected: headache, vertigo, insomnia, hemiplegia, seizures, psychological difficulties
- when parenchymal tissue is affected: paresis, altered intellect, paranoia, illusions, hallucinations, Argyll Robertson pupil, ataxia, slurred speech, trophic joint changes, positive Romberg's sign and facial tremor
- Late Benign syphilis
- gummas (chronic, superficial or deep, granulomatous nodular lesions that develop 1 to 10 years after infection on the skin and muccocutaneous tissues
- lesions affecting bones and other organs
- Cardiovascular syphilis
- decreased cardiac output that leads to decreased urine output, decreased sensorium as a result of hypoxia, pulmonary congestion
- deterioration of the aortic valve and aorta
http://www.fpnotebook.com/ID214.htm - Syphilis on Family Practice Notebook. Lists all stage and symptoms along with treatment.