Originally Posted by ERTraumaJunkie
Just curious. As popular as it is in this part of the country, I'm very thankful I've only seen one meth OD so far. I'm sure it won't be the last. Just wondering if we went about treating the right way: i.e, fluid bolus, external cooling, MASSIVE quantities of benzos. Any other suggestions? This was a first for everyone in the ER. Thanks!
It sounds like you did the right thing. Generally you will see cns agitation along with cardiac excitement with methamphetamine. Just be careful when you say meth because it can be confused with methadone. There really isnt an antidote, just management of the symptoms.
With a drug overdose, one of the main concerns is that you are causing GABA stimulation so when you have seizures traditional treatments like Dilantin are not that effective, hence why you give the massive amount of benzos which help to inhibit the stimulation. Generally if someone is hyperthermic with an amphetamine overdose it is coming from muscle activity in the form of tremors or seizures. So control of seizures, agitation and tremors is of the upmost importance which can also lead to rhabdomyolysis. If Benzos are not effective (and yes you have to give more than 1 or 2 mg of Ativan) then look at phenobarb.
Benzos will also help with the tachycardia and hypertension but if they are not effective you may have to go other routes. As far as the fever goes, it really depends. Most of the time you dont want to paralyze someone who has taken a drug overdose as as paralyzed pt will not display s/s of seizure activity however the electrical activity will still be going on in the brain. RSI is typically ok but I would hesitate to use continued paralysis. Diprivan is great to use along with benzos. So treat the fever with benzos, passive cooling initially.
If the temperature is extremely high, not responding then definitely inducing paralysis is the most effective intervention. But the pt would need continuous EEG monitoring at the bedside so seizures could be detected. Also consider possibility of malignant hyperthermia or neuro malignant syndrome.
The following members say Thank You: