I'm not sure about Cymbalta or Effexor, but I've had first hand experience with Lexapro.
I was on it for about 5 months... I had to get off of it because of the awful sexual side effects. Getting off it was really hard. I was taking 10 mg qd, then I had to taper off slowly. It took me about 1 1/2 months to finally get off of it totally. The withdrawal sx can be brutal!
I'm not taking any antidepressants now. I am exercising and eating right, and I feel great. Don't think I'll ever venture down the "antidepressant road" again. For me, there are better alternatives
I hope this was helpful.
Best,
Diane