Interesting... never knew this.
We regularly co-infuse propofol with NS maintenance or boli... nobody's ever said a word about it, including our clinical druggists who sometimes set up the prop for us when we've got a hot mess going on.
I'm reading in Davis, 12e which says, "Usually administered undiluted. If dilution is necessary, use only D5W."
We're not talking about dilution, though (are we?), we're talking about co-infusions or Y-site compatibility.
Under "Solution Compatibility," it says: " D5W, LR, D5/LR, D5/0.45% NaCl, D5/0.2% NaCl" while saying nothing about any maintenance fluids under "Y-Site Incompatibility."
Its " Y-Site Compatibility" list is extensive and includes NaHCO3, KCl, MgSO4 as well as a lot of abx, pressors, and narcs.
As far as a dedicated line, I see no reason for it... nor is there always such a luxury in the ED.