Phenergan Supp given to toddler; child dies

Our pedi unit frequently gave phenergan --both supp and po -- (supp most frequently). Rarely more than 12.5 dose and I can't recal giving to any little ones under two. That doesn't mean that it never happened, but I can't recall any instances when we had trouble r/t phenergan --

Just another reason that ER staff should have solid pedi knowledge base in addition to all the other stuff they need to know!!! Dosages, drip rates, assessment parameters, etc. are often so vastly different from adult standards!!! Pedi patients are NOT just little adults -- their little systems are in constant states of grwoth and change -- so delicately balanced!

My heart goes out to you and your friend! It is sad when any patient dies in that kind of situation -- but truly terrible when a child dies! May God comfort and sustain you and your friend in this time of loss!

Well there are some other questions that come to my mind when I read your post.

How long had the child been vomiting? To what degree was this child dehydrated? Indicators such as sunken eyes, dry mucous membranes and last void would be indicative of that. I worked in the ER for many years. We saw kids all the time with GI bugs, vomiting and very often would give them phenergan supps to alleviate the symptoms. Not all children who are vomiting need a full work up, IV and admission, however, a thorough assessment has to be done to come to that decision.

The pediatric dosing for a child with vomiting is 0.25-1 mg/kg with a max of 25mg PO/PR/IM. The biggest thing with Phenergan is that it has a sedating effect. So if the child was on any other medication that caused CNS depression or was lethargic to begin with this could pose respiratory depression issues.

If the dosing was accurate based on the child's accurate weight (you said under two years old, how much under two?) And the accurate amount was indeed given, and the child was not on any other meds that are contraindicated or was not allergic, I would be more inclined to think that there was an underlying reason for the child's death. I wouldn't think the Epi is an issue at all since I assume they only gave that onces the childed coded.

More things I would ask are:

Was the child lethargic?
Fever?
Did the child arrest in the ER?
Past medical history etc...

I have never had any problems with phenergan in pediatric patients.

My heart goes out to your friend. How devastating it must be to lose a child.

Robin

wow...
in the ED i work at, we tend to give phenergan PR often. With symptoms worsening as was described to you (vomiting blood?) There should be other intervention. The epi is pretty much out of the question ( The child had arrested) What I have seen in the ED with kids usually has to be extreme dehydration. I have seen kids that are lethargic turn right around with the old 20cc/kg bolus or if needed repeated... Anytime the ED that has a kid crumps it rips everyone apart. There is so much more info needed.
my heartaches for the family....

Children tend to show signs of decompensating hypovolemic shock later than adults, when they go "off the deep end". Pals teaches you to prevent the arrest. it doesnt hurt to give the child a bolus or even two.

any child with vomiting should be given IV fluids, or a PO challenge with pedialyte. it sounds to me like this child got lost in the shuffle. either that, or they gave the kid the wrong sized supp, maybe a 50.

my sincerest condolences to you and your friend.

First of all, I am extremely sorry for your friend's loss.

A few things regarding phenergan and peds:

1) We used to give it all the time to kids under 2. We would even cut a 12.5 in half (not the best practice because the medication is not equally distributed throughout the suppository).

2) I thought it strange that my child's pediatrician would not prescribe phenergan for n/v because she was < 2 years old. Yet we gave it all time in the ER.

3) We now have a policy in the hospital that Phenergan is not to be given to toddlers younger than 2. By the way, I never saw a negative outcome from it. The worst case I saw was a ~ 9 y.o. who experienced some dyskinthesia.

4) Here is the link to the pharmaceutical label stating that Phenergan is CONTRAINDICATED in children younger than 2:

http://www.wyeth.com/content/ShowLabeling.asp?id=127

5) What is the purpose in starting a hep lock on a dry kid? That part makes absolutely no sense. If you are going to go to the trouble to start a line, you might as well give a 20ml/kg bolus and see how the kid responds.

6) As far as the suppository being a 50mg one, our Phenergan supp's are all the same size. They are different colors (I think).

Again, my condolences.

regarding the cutting of the supp, the supp is supposed to be cut lengthwise, from the point of "the bullet" down. if you cut them in half, the medicine isnt even. i hope this makes sense.

Yep, yep, yep. When learning the emergency care of children, that is one of the things they drill into your head. Kid's vital signs can be completely normal for a very long time as their bodies compensate for things like hypovolemia. Then they get to a point where they can't compensate anymore...and they just crash. So I agree, any child that has been vomiting that much (to the point of vomiting blood) and had a heplock already in place should have gotten some IV fluids. A bolus, a running line, something, anything. Dehydration is deadly in children, and the smaller they are, the harder it can hit them. This stands out to me much more than the phenergan suppository.