Elevated troponin with renal failure? - page 2
by thelema13 10,416 Views | 17 Comments
Recently left a 12 lead class, instructor stated troponin I and T can be elevated in renal failure pts. When asked how/why, she could not give an answer. Looking at my resources, I cannot find an answer either. Does anyone know... Read More
- 2Oct 25, '11 by CraigB-RNJust in case you can't sleep tonight, here's some light reading on the subject
- 1Oct 31, '13 by rdrcrnawannabeTroponin I and T are reliable and preferred markers for cardiac damage in patient population with NORMAL renal function.
Troponin T (TnT) is typically elevated in chronic renal failure. There are several theories with no strictive measurements on how this is diagnosed. From what I have read, most cardiologists seem to think it is due to myocardial stunning, which produce higher levels of an unbound cytosolic pool of TnT (myocardial stunning is defined as a 20% reduction in segmental wall motion at rest with evidence of recovery after hemodialysis).
Other theories include left ventricular hypertrophy, endothelial dysfunction, loss of membrane integrity due to the leakage of troponin, ongoing microinfarctions, and sub-slinical cardiac damage exacerbated by reduced renal clearance. Overall, the concentration of TnT is directly related to the GFR/renal clearance.
Regardless of the cause, studies have shown an increase in mortality in renal failure patients whose troponins are elevated; elevations in TnT are predictors of increased mortality and worsening long term cardiovascular outcomes, especially in the presence of known coronary artery disease. The question remains when to treat elevated troponins in the absence of cardiac-related symptoms; some question the need for more aggressive therapy for atherosclerotic disease or PCI in the asymptomatic patient. Post-ischemic cardiac dysfunction can occur following hemodialysis, so it is recommended to obtain baseline markers prior to this.
The best advice is to monitor serial troponins and EKG changes; many of ESRD patients have cardiomyopathy in the setting of left ventricular hypertrophy.
- 2Nov 6, '13 by Esme12 Senior ModeratorQuote from CialeI would say after being defibrillated 6 times in the field makes a trop a lower priority.So maybe that's why the doc didn't order a POC Trop on my unresponsive pt the other day...they had already shocked him 6 times in the field so seems like a POC trop would be irrelevant?
- 0Nov 10, '13 by IkikaeruHad a pt with slightly elevated Troponin levels the other day and the ER doc stated it was probably due to her dehydration. He even consulted a cardiologist friend and he agreed. Personaly I didnt know that was something that could elevate it.
Learn something new every day.
- 0Dec 7, '13 by EmergentQuote from AJPVGreat information, thanks!I've just been reading some studies showing that habitual coffee drinking is protective to the kidneys and results in increased GFR over non-coffee drinkers. It results in decreased nephropathy in both non-diabetics and diabetics, and it decreases the incidence of glucose intolerence & type 2 diabetes. I wonder if I can include that among my teaching points.