In people with T1DM why doesn't their endoginous glucagon kick in to raise BG when they are hypoglycemic? Are the pancreatic alpha cells also destroyed with the onset of the disease? I can't remember from nursing school.
Mar 9, '10
There is an impairment of the autonomic nervous system that occurs in Type 1 DM, resulting in a failure of the alpha cells of the pancreas to respond normally to hypoglycemia.
Mar 11, '10
sometimes the body just cannot catch up to the demand.
Jun 16, '10
Alpha cells work in response to beta cells. So if there are no beta cells then the alpha cells can't function properly.
Jun 17, '10
Glucagon comes from the liver. The pancreas sends a message to the liver to release glucagon. If the pancreas is faulty, then the messages may be faulty.
Jun 18, '10
Yes, and alpha cells are what send the message to the liver to start producing glucagon when sugars drop.