Glucagon in T1DM

  1. Hi All:
    In people with T1DM why doesn't their endoginous glucagon kick in to raise BG when they are hypoglycemic? Are the pancreatic alpha cells also destroyed with the onset of the disease? I can't remember from nursing school.
  2. Visit Gampopa profile page

    About Gampopa, BSN

    Joined: May '03; Posts: 163; Likes: 77
    M/S Nurse; from US
    Specialty: 10 year(s) of experience in Adult M/S


  3. by   country mom

    There is an impairment of the autonomic nervous system that occurs in Type 1 DM, resulting in a failure of the alpha cells of the pancreas to respond normally to hypoglycemia.
  4. by   classicdame
    sometimes the body just cannot catch up to the demand.
  5. by   JPORCH
    Alpha cells work in response to beta cells. So if there are no beta cells then the alpha cells can't function properly.
  6. by   classicdame
    Glucagon comes from the liver. The pancreas sends a message to the liver to release glucagon. If the pancreas is faulty, then the messages may be faulty.
  7. by   JPORCH
    Yes, and alpha cells are what send the message to the liver to start producing glucagon when sugars drop.

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