Sugamadex

  1. anyone used this or heard anything more about when it comes out?
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  2. 7 Comments

  3. by   JimandAmi
    As far as I know, it is in Phase 3 clinical trials right now with about 10 trials being conducted. They are hoping it will be available next summer or later.
  4. by   mced
    I have heard that is should be available for general use within two years. Looking forward to its arrival. Giving someone poison to reverse paralysis seems a bit odd.
  5. by   propofool
    Quote from mced
    I have heard that is should be available for general use within two years. Looking forward to its arrival. Giving someone poison to reverse paralysis seems a bit odd.
    Poison? What do you mean? What do you know about Sugamadex?
  6. by   Focker
    I think he meant anticholinesterases like neostigmine, pyridostigmine, edrophonium, etc. They work by the same mechanism as nerve gas, binding cholinesterase, increasing levels of acetylcholine. Nerve gas (organophosphates) do it to the point where a type II paralysis occurs and you die from respiratory failure.
  7. by   mced
    Quote from propofool
    Poison? What do you mean? What do you know about Sugamadex?
    Focker got the poison gimmick. Sugammadex is an upcoming drug. Basically it is a cyclodextrin that specifically encapsulates aminosteriods such as rocuronium, vecuronium, and to a lesser extent, pancuronium. It completely reverses paralysis regardless of the patient's twitch response. There is a professor in my program that has done a few lectures on this product. Hopefully will be out for general use within a year or so.
  8. by   propofool
    Quote from mced
    Focker got the poison gimmick. Sugammadex is an upcoming drug. Basically it is a cyclodextrin that specifically encapsulates aminosteriods such as rocuronium, vecuronium, and to a lesser extent, pancuronium. It completely reverses paralysis regardless of the patient's twitch response. There is a professor in my program that has done a few lectures on this product. Hopefully will be out for general use within a year or so.
    Thanks for the clarification. That's the problem with this type of discussion, you can miss the nuances.
  9. by   HyperTension
    Here isa pretty good link with regards to the action / binding of sugammadex.

    http://en.wikipedia.org/wiki/Sugammadex

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