You've probably already read my opinion on this, so I will try not to be too wordy <g>
My suggestion to new grads is to start out in a busy, tertiary, urban center. You want some place that does everything-hearts, OB, neuro, etc, etc. A place you will work your behind off for the first couple of years.
I beleive there are lots of benefits to this. You will more likely have lots of backup and support. You will be exposed to lots of serious, difficult, complicated cases. When you first get out of school is the best time to be exposed to this type of working environment, and develop these skills. They will last you a lifetime. If you start your career in a smaller, more limited, rural workplace, you will not get the chance to develop to your full potential, and--yes, I do think it would be harder to later transition to a large urban center.
Yes, the rural jobs offer more money. Very often they have a limited number of staff. You may be the only CRNA, or one of only 2-3. It takes a great committment to work in these places, and it takes a good salary to get that kind of committment. And they will want their money's worth. A rural CRNA usually needs to have a very high level of independent decision making ability.
I understand that some graduates may feel that their education was so rigorous, that they already meet this criteria. I do not believe this is true for any new grad I have ever been involved with. (Of course, there may be regional variation, and maybe there are some programs that do produce such graduates)
No matter how hard you have worked, you always had that safety net. There was always a clinical instructor available. Every graduate I have ever talked to has commented on the difference they feel without that safety net. To know your decisions are truly your own, and you have to live with the consequences. It is something that just doesn't happen until after graduation.
The best CRNAs are those that realize that graduation is when the real learning STARTS. If you pay your dues for the first couple of years, you will not only maximize your own abilities, you will be making an investment in your future marketability, and making your services that much more valuable in the rural environment.
OK, maybe that was wordy after all. Thanks for listening.