Re: Physostigmine + Neostigmine Originally Posted by piper77 Hate to disagree with you, jwk, but physostigmine is, of course, a cholinesterase inhibitor, and has LONG been used as a reversal agent - don't know where you came up with idea that it has no indications as one. That being said....I certainly don't see it being used much these days at all, and have not seen any combinations as described above. Devine....sounds like an interesting mini-research project......My guess is that you will find most clinicians don't use it at all anymore. Good luck!
OK, an ACH inhibitor it is, but in 25 years, I've never seen it used for reversing NMB's. I've got a few old-fashioned tricks up my sleeve as well, but this isn't one of them.
However, I'll stand by my statement that if you have "no solid reasoning for doing so" then you shouldn't be giving any drug or treatment. If you don't have a reason for, or understand why you're doing what you're doing, then don't do it. And just doing it because someone else told you it was neat to do years ago? Not a good reason either.
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