Allergic Reactions

  1. Hi RNs,

    I know the standard of care for an allergic reaction in ER is Solumed, Benedryl, and Randine. I understand the Solumed and Benedryl, but what roles does the Randine play?

  2. 3 Comments

  3. by   meandragonbrett
    Ranitidine is a Histamine2 antagonist.
  4. by   TDFlMedicRN
    Quote from meandragonbrett
    Ranitidine is a Histamine2 antagonist.
    To elaborate somewhat; it is believed that H2 histamine blockers in conjunction with H1 blockers such as diphenhydramine have a synergistic effect; in other words, the two drugs potentiate each other when given together in the presence of a histamine reaction. This is an off-label use of an H2 antagonist, by the way.

    Additionally, H2 blockers can relieve the increased acid production which is a potential after effect of the catecholamine dump that will almost assuredly occur in a true histamine reaction.

  5. by   BlessedMomRN
    thanks much!