Dipyridamole (Persantine)

Specialties Cardiac

Published

Specializes in Oncology, Dermatology, Cardiology.

I am looking up medication classifications and as I come across Dipyridamole (Persantine) its classification is Antiplatelet. I thought it was used for a stress test. How are these two related? The MOA "Exact mechanism unknown inhibits platelet adhesion; dilates coronary arteries".

Specializes in critical care: trauma/oncology/burns.

Hello BostonNurse:

Yes, you are correct. Persantine or Dipyridamole inhibits thrombin formation when given long term and causes vasodilation when given in high doses for the short-term.

1) Used to lower pulmonary HTN without big drop in SBP

2) inhibits formation pro-inflammatory cytokins

3) increases release of t-PA from the brain's microvascular endothelial cells

4) increases myocardial perfusion and left ventricular function in patients with ischemic cardiomyopathy

5) used for patients with brain attack/stroke to inhibit plt aggregation or clumping (see # 2)

athena

Specializes in Oncology, Dermatology, Cardiology.

Where did you get this information OR is this what you already know in your 33 years of working :)

Specializes in critical care: trauma/oncology/burns.

Boston:

Gosh, I wish I could say detailed information like that I gathered from my years as an RN. Waaay back in the day when my hospital first starting doing fem-pop bypass or fem-fem bypass this was the drug of choice (mid-70's)

--> Studying for the CCRN, attending the Army critical care 8A nurse course .

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