Advice what to do????

I am exhausted from sending out numerous applications, driving handing in apllications, making rounds to Nurse managers offices to introduce myself, and calling billions of stiffs. I graduated in may 2008, super excited to be starting my new carrer as a nurse, as it's my passion to work with people ever since I can remember, but it a has been over a year now and I am at a crossroads in my search now. I don't know what to do, when is it time to give up with the search and start something different? I am poor, jobless and hopeless right could anyone shed some light on this super dark situtation.

Thanks,
Lost and confused nurse