I have experience as a teacher, not a nurse, in Northern Arizona on the reservation. I can tell you that it is very remote, you will have to drive 40-50 miles to go to get groceries, and things like that. Some companies do not deliver to P.O. boxes. I did rely on Amazon.com a lot, but the mail and delivery took longer than usual as well. Many of the places will not deliver to employee housing, so you have to get a P.O. box to get the packages and things like that delivered. There were no banks, restaurants, or stores for 50 miles. There was a small gas station that sold a few supplies, and that was about it.
I found it frustrating living in such a remote area, and often was bored. I found that some of the Native people were thankful for us, while others still despised the white people. Also, the medical care in our situation was very primitive and limited. It will be a cultural shock for sure if you come from a big city like I did before I moved to Arizona.
Culture wise they do have festivals and things like that, and sometimes they will invite you to their tribal activities. There was a clear divide between the white staff members and the natives who seemed to despise us. This was just my experience, so take it with a grain of salt. With that being said, I don't think I would do it again. The schools were very poor so if you have children, I would not recommend living there. I also felt unsafe at times, and would not go places alone.